Chronic lymphocytic leukemia, hypogammaglobulinemia and autoimmune hemolytic anemia--an experiment of nature.
نویسندگان
چکیده
BOUT a third of the patients with chronic lymphocytic leukemia develop hypogammaglobulinemia at some time or other during the course of their illness.’” The ensuing clinical manifestations are usually no different from those encountered in hypogammaglobulinemia from other causes; the patient may manifest an “immunologic paralysis” and is thereby rendered susceptible to infections of various kinds.7 The high incidence of “autoimmune” hemolytic anemia in chronic lymphocytic leukemia is also well recognized.5 In this complication, accelerated destruction of erythrocytes is associated with attachment of a protein to the patient’s erythrocytes as demonstrated by the Coombs antigbobulin reaction. We had the opportunity to study a patient who had the rather unusual combination of chronic lymphocytic leukemia, hypogammagbobulinemia and hemolytic anemia associated with a positive antigbobulin reaction in which the erythrocytes were shown to be coated with gamma globulin. In view of continuing evidence of “autoantibody” formation, despite hypogammaglobulinemia, our attention was directed to the manufacture of other antibodies to known antigens. In addition, information was sought relative to the “autospecificity” of the antiglobulin reaction as manifested by the possible affinity of parenterally administered labeled normal human gamma globulin for the patient’s erythrocytes. The purpose of this paper is to present the results of these studies.
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عنوان ژورنال:
- Blood
دوره 15 شماره
صفحات -
تاریخ انتشار 1960